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目的研究大叶小檗根的水、乙醇提取物对小鼠的抗炎镇痛作用。方法采用二甲苯、巴豆油致小鼠耳廓炎症、扭体法和热板法制作疼痛模型来观察大叶小檗根水、乙醇提取物的抗炎镇痛作用。结果大叶小檗根的水、乙醇提取物能显著抑制二甲苯和巴豆油引起的小鼠耳廓炎性肿胀,明显降低冰醋酸致小鼠的扭体次数,提高小鼠的痛阈值。结论大叶小檗根的水、乙醇提取物均具有较好的抗炎镇痛作用。
Objective To study the anti-inflammatory and analgesic effects of water and alcohol extracts from the roots of Bletilla striata. METHODS: The anti-inflammatory and analgesic effects of root water and ethanol extracts of Bletilla striata were observed by xylene and croton oil-induced mouse ear inflammation, writhing and hot plate method. RESULTS Water and ethanol extracts from roots of B. macrophylla significantly inhibited the inflammatory swelling of the ear caused by xylene and croton oil, significantly reduced the number of writhing in mice induced by glacial acetic acid, and increased the pain threshold in mice. Conclusion The water and ethanol extracts from the roots of Bletilla striata have good anti-inflammatory and analgesic effects.