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目的 :观察寒喘平、热喘平对哮喘模型豚鼠血浆TXB2 、 6-keto -PGF1α的影响。方法 :用 1 0 %卵白蛋白液致敏豚鼠 ,两周后再用 1 %该溶液雾化吸入 ,以诱发豚鼠哮喘 ,测定豚鼠血浆TXB2 、 6-keto -PGF1α水平。结果 :模型组豚鼠 6-keto -PGF1α降低 ,TXB2 升高 ,与正常组比较具有显著性差异 (P <0 .0 1 )。而寒喘平、热喘平组能够明显升高血浆 6-keto -PGF1α、降低血浆TXB2 ,与模型组比较具有显著性差异 (P <0 .0 5,0 .0 1 )。结论 :寒喘平、热喘平升高PGI2 和降低TXA2 可能是治疗哮喘的作用机理之一。
Objective: To observe the effects of cold-abating and heat-stroke on TXB2 and 6-keto-PGF1α in asthmatic guinea pigs. METHODS: The guinea pigs were sensitized with 10% ovalbumin and two weeks later, they were inhaled with 1% solution to induce asthma in guinea pigs. Plasma levels of TXB2 and 6-keto-PGF1α in guinea pigs were measured. Results: The 6-keto-PGF1α and TXB2 in the guinea pigs in the model group were significantly decreased (P < 0.01). The Hanchuanping and Hotchuanping group could significantly increase plasma 6-keto-PGF1α and decrease plasma TXB2, which was significantly different from the model group (P < 0.05, 0.01). Conclusion : The increase of PGI2 and decrease of TXA2 by Hanchuanping and Hotangping may be one of the mechanisms of asthma.