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目前认为,活化诱导的淋巴细胞凋亡在许多疾病的发病机制中起重要作用,但其在慢性乙型肝炎中的作用研究较少。为此,我们应用流式细胞仪,对乙型肝炎患者外周血淋巴细胞的凋亡进行检测,并结合临床资料进行分析,探讨其在慢性乙型肝炎发病机制中的作用。 1 材料和方法 1.1 材料 我院1998年住院的乙型肝炎患者43例,男32例,女11例,年龄17岁～61岁,平均33岁±8岁。诊断按1995年全国病毒性肝炎会议标准,24例行肝穿组织活检术,肝组织炎症活动分级按Scheuer标准。正常对照15例取自献血员。
Currently, activation-induced apoptosis of lymphocytes plays an important role in the pathogenesis of many diseases, but its role in chronic hepatitis B is less studied. To this end, we used flow cytometry to detect the apoptosis of peripheral blood lymphocytes in patients with hepatitis B, and combined with clinical data analysis to explore its role in the pathogenesis of chronic hepatitis B. 1 Materials and Methods 1.1 Materials Hospital in our hospital in 1998, 43 cases of hepatitis B patients, 32 males and 11 females, aged 17 years to 61 years, mean 33 years ± 8 years. According to the 1995 National Conference on Viral Hepatitis, 24 biopsies of liver biopsy were performed. The grade of inflammatory activity in liver tissue was classified according to Scheuer’s criteria. 15 cases of normal controls were taken from blood donors.