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目的观察5-氨基酮戊酸(5-ALA)光动力疗法(PDT)治疗男性尿道口尖锐湿疣的疗效、安全性及复发情况。方法将60例男性尿道口尖锐湿疣患者随机分成ALA-PDT治疗实验组和液氮冷冻治疗对照组各30例,实验组用10%5-ALA霜封包皮损3h,再用635红光照射20min(能量密度126J/cm2),对照组用液氮反复冻融皮损3次,比较两组的有效率、治愈率、复发率和不良反应。结果实验组患者经过1～3次光动力治疗,有效率100%,治愈率86.67%,复发率13.33%,不良反应主要为局部轻微灼伤、疼痛和刺激。对照组患者经过1～3次冷冻治疗,有效率为100%,治愈率60.00%,复发率40.00%。不良反应重,主要为溃疡、疼痛和瘢痕形成。结论 ALA-PDT治疗尿道口尖锐湿疣有效率和治愈率高,复发率低,不良反应小。
Objective To observe the efficacy, safety and relapse of 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) in the treatment of male urethral condyloma acuminatum. Methods Sixty male urethral condyloma acuminatum patients were randomly divided into ALA-PDT treatment group and liquid nitrogen freezing treatment group, 30 cases in each group. The experimental group was treated with 10% 5-ALA cream for 3 h, then the 635 red light irradiation for 20 minutes (Energy density 126J / cm2), the control group was repeatedly frozen and thawed with liquid nitrogen for three times. The effective rate, cure rate, recurrence rate and adverse reactions of the two groups were compared. Results After 1 to 3 photodynamic therapy in the experimental group, the effective rate was 100%, the cure rate was 86.67% and the recurrence rate was 13.33%. The adverse reactions were mainly minor burns, pain and irritation. Control group of patients after 1 to 3 cryotherapy, the effective rate was 100%, the cure rate was 60.00%, the recurrence rate was 40.00%. Adverse reactions, mainly for ulcers, pain and scar formation. Conclusions ALA-PDT is effective and effective in the treatment of urethral condylomata acuminatum, with a low recurrence rate and a small adverse reaction rate.