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为研究ＥＥ精子毒性及生物效应标志物，对ＰＳ版作业男工ＬＤＨ－Ｃ４活性／精子毒性进行调查，同时对小鼠附睾组织匀浆ＬＤＨ－Ｃ４活性测定。结果表明接触ＥＥ在７７ｍｇ／ｍ３以上男工精液ＬＤＨ－Ｃ４活性受到抑制。随着接触水平增加，ＬＤＨ－Ｃ４活性下降越明显，呈明显的剂量－反应关系。在２４３ｍｇ／ｋｇ剂量以上，小鼠ＬＤＨ－Ｃ４活性也显著下降，亦有相同的规律，提示ＬＤＨ－Ｃ４活性降低可以作为精子毒效应评价指标。
In order to study EE sperm toxicity and bioeffect markers, LDH-C4 activity / sperm toxicity in male PS workers was investigated, and LDH-C4 activity in mouse epididymal homogenate was also measured. The results showed that the activity of LDH-C4 in male semen was inhibited when EE was above 77mg / m3. With the increase of exposure level, LDH-C4 activity decreased more significantly, showing a significant dose-response relationship. At the dose of 243mg / kg, the LDH-C4 activity in mice also decreased significantly. The same rule was also observed, suggesting that LDH-C4 activity could be used as an indicator of sperm toxicity.