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用小鼠、兔及犬研究了三尖杉酯碱(HA)和高三尖杉酯碱(HO)的毒性。兔及犬连续给药五或七天,两药毒性的主要靶器官都是胃肠道、心脏和造血器官。大多数毒性死亡皆可归因于心功能障碍。用致死剂量时,尚个别出现轻、中度肝、肾损害。间歇地重复给药共三疗程,未出现其它重大毒性,但心脏及造血显示为轻、中度累积性的毒性,毒性与剂量大小平行,可及时发现,停药后是完全可逆的。在至少六周的观察期内未见重大迟发毒性,两药均未见种属间、个体间或与性别有关的毒性性质上的显著差异。HA及HO的家犬中毒剂量(高)分别是0.45mg/kg/天×5及0.16mg/kg/天×7。小鼠急性LD_(50)(±S.E.)分别是4.17±0.30及3.17±0.19mg/kg。HA与HO相比,两者毒性在性质上无重大差别,程度上则HO显著大于HA。
Toxicity of harringtonine (HA) and homoharringtonine (HO) was studied in mice, rabbits and dogs. Rabbits and dogs were given five or seven days in a row, and the main target organs for both drugs were gastrointestinal, cardiac and blood-forming organs. Most toxic deaths are attributable to cardiac dysfunction. With lethal dose, there are individual mild to moderate liver and kidney damage. Intermittent repeated administration of a total of three courses, no other significant toxicity, but the heart and hematopoietic showed mild and moderate cumulative toxicity, toxicity and dose size parallel, can be found in time, is completely reversible after stopping. No significant late-onset toxicity was observed over a period of at least six weeks of observation, and no significant differences in the nature of the inter-genus, individual, or gender-related toxicity were observed with either drug. Domestic dog poisoning doses (high) for HA and HO were 0.45 mg / kg / day x 5 and 0.16 mg / kg / day x 7, respectively. The mouse acute LD 50 (± S.E.) was 4.17 ± 0.30 and 3.17 ± 0.19 mg / kg, respectively. Compared with HO, HA has no significant difference in toxicity and HO is significantly greater than HA.