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目的研究居室氡暴露与肺癌危险的关系。方法采用巢式病例-对照研究设计,病例与对照为1∶2个体配比。以面访的方式访问调查对象的家属或其他知情人。用固体核径迹探测器方法,对调查对象曾住房屋的氡浓度进行累积测量。结果成功访问了63例肺癌病例和125例对照,病例与对照的平均死亡年龄分别为60.1岁和60.6岁。病例和对照所在室内氡的平均浓度分别为40.1和39.2 Bq/m3。单因素条件logistic回归分析氡暴露与肺癌危险的关系,比值比[(OR)95%可信限(95%CI)]为1.25(0.63~2.52)。不同程度氡暴露,肺癌危险有增加趋势,但差异无统计学意义(P>0.05)。在100 Bq/m3氡浓度时,氡暴露的超额比值比(EOR)为0.30(95%CI:-0.53~14.93),调整钍射气贡献后,EOR=0.14。结论未发现室内氡暴露与肺癌危险有统计学意义的关联。
Objective To study the relationship between indoor radon exposure and lung cancer risk. Methods The nested case-control study was designed with a 1: 2 ratio of patients and controls. Interview the interviewee’s family members or other insiders. With the solid nuclear track detector method, the cumulative concentration of radon concentration in the surveyed houses was measured. Results A total of 63 cases of lung cancer and 125 controls were successfully interviewed. The average age of death was 60.1 years and 60.6 years respectively. The average concentrations of indoor radon in cases and controls were 40.1 and 39.2 Bq / m3, respectively. Single factor conditional logistic regression analysis of radon exposure and risk of lung cancer, odds ratio (OR 95% CI (95% CI)] was 1.25 (0.63 ~ 2.52). Different degrees of exposure to radon increased the risk of lung cancer, but the difference was not statistically significant (P> 0.05). At a radon concentration of 100 Bq / m3, the excess ratio of exposure to radon exposure (EOR) was 0.30 (95% CI: -0.53 to 14.93) and the EOR was adjusted to 0.14 after adjusting for thoron contribution. Conclusions There was no statistically significant correlation between indoor radon exposure and lung cancer risk.