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Toll样受体是一组Ⅰ型跨膜受体 ,通过识别入侵病原微生物的配体 ,激发天然免疫应答 ,启动促炎症细胞因子和共刺激分子的表达。Toll样受体在信号转导中发挥重要作用 ,MyD88是信号转导通路中的关键蛋白。通过对Toll样受体的研究有助于进一步认识宿主的免疫反应。
Toll-like receptors, a group of type I transmembrane receptors, stimulate innate immune responses by recognizing ligands that invade pathogenic microorganisms and initiate the expression of pro-inflammatory cytokines and costimulatory molecules. Toll-like receptors play an important role in signal transduction. MyD88 is a key protein in signal transduction pathway. Through the study of Toll-like receptors help to further understand the host’s immune response.