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1990年1月至12月应用流式细胞仪和T细胞单克隆抗体检测了40例鼻咽癌患者在放疗前,放疗结束时,放疗结束后2个月及1年时外周血T细胞亚群的分布。结果表明,放疗前鼻咽癌患者总T细胞明显低于正常人(P<0.01),T_4(辅助/诱导)细胞百分比明显下降(P<0.001),T_8(抑制/细胞毒)细胞百分比上升。T_4/T_8比值在晚期病人中显著倒置。放疗前后总T细胞变化不大。T_4/T_8比值继续下降,放疗后2月最为明显。放疗后1年T_4/T_8比值开始上升,但仍然低于放疗前。作者发现,鼻咽癌患者放疗前和放疗后1年的T_4/T_8比值与预后呈现一定的关系。
From January to December 1990, flow cytometry and T-cell monoclonal antibodies were used to detect T-cell subsets in 40 patients with nasopharyngeal carcinoma before radiotherapy and at the end of radiotherapy at 2 months and 1 year after radiotherapy. Distribution. The results showed that the total T cells of patients with nasopharyngeal carcinoma before radiotherapy were significantly lower than normal (P<0.01), the percentage of T4 (helper/inducer) cells decreased significantly (P<0.001), and the percentage of T8 (inhibitory/cytotoxic) cells increased. The T4/T8 ratio was significantly inverted in advanced patients. Total T cells did not change much before and after radiotherapy. The ratio of T_4/T_8 continued to decline, with the most obvious in February after radiotherapy. The ratio of T_4/T_8 began to increase 1 year after radiotherapy, but it was still lower than before radiotherapy. The authors found that the ratio of T4/T_8 before radiotherapy and 1 year after radiotherapy in patients with nasopharyngeal carcinoma showed a certain relationship with the prognosis.