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调查了５种软木接尘工人共５８４人的外周血淋巴细胞微核率，发现均可诱发微核细胞率的增高。以对照组９５％正常上限０．４％作为判断微核阳性的标准，接尘工人的微核阳性率明显高于对照组（Ｐ＜０．０１）。并随工龄的增长而增高，具有明显的剂量、时间—反应关系（ｒ＝０．９０，Ｐ＜０．０１）。五种软木的接尘工人微核阳性率：椴木３６．２％，冷杉２６．３％，白皮松１５．７％，桦木９．６０％，杨木２．１０％。其中椴木和冷杉与对照组相比均有非常显著的差别（Ｐ＜０．０１）。五种软木尘的水提取液均可诱发小鼠骨髓ＰＣＥ微核率的增高，并均有明显的剂量—反应关系，相关系数椴木为０．８６，冷杉为０．６０，白皮松为０．３９，桦木为０．７６，杨木为０．７３；除白皮松Ｐ＜０．０２外，其他４种软木均Ｐ＜０．０１。在１５ｇ／ｋｇ体重剂量下微核率以椴木为最高（０．８０％），依次为冷杉（０．７１％）、桦木（０．６５％）、白皮松（０．６３％）、杨木（０．４３％）。动物试验结果与接尘工人外周血淋巴细胞微核阳性率趋势基本一致。表明软木尘中含有能损伤染色体的物质。
A total of 584 peripheral blood lymphocyte micronucleus rates were investigated in five kinds of cork dusting workers and found that the micronuclei could be increased. The 95% normal upper limit of 0.4% in the control group was used as the criterion to determine the positive rate of micronuclei. The positive rate of micronuclei in workers exposed to dust was significantly higher than that in the control group (P <0.01). And increased with the increase of working age, with obvious dose-time-response relationship (r = 0.90, P <0.01). Five kinds of cork dust workers exposed to the rate of micronuclei: basswood 36.2%, fir 26.3%, Pinus bungeana 15.7%, birch 9.60%, poplar 2.10%. Among them, basswood and firs had very significant difference compared with the control group (P <0.01). Five aqueous extracts of cork dust could induce micronuclei of PCE in mouse bone marrow, and all had significant dose-response relationship. The correlation coefficient was 0.86 for basswood, 0.60 for fir and 0 for white bark. 39 for birch, 0.76 for birch and 0.73 for poplar; P <0.01 for all four cork species except Pinus bungeana P <0.02. Under the dose of 15g / kg body weight, the frequency of basswood was the highest (0.80%), followed by fir (0.71%), birch (0.65%), white bark (0.63% (0.43%). Animal test results and workers exposed to dust the trend of the positive rate of peripheral blood lymphocytes micronucleus basically the same. That cork dust contains substances that can damage the chromosomes.