In this study,mesoporous bioactive glass particles (MBGs) are incorporated into poly(lactic-co-glycolic acid) (PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide (scCO2) foaming method.Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming strategy.Specifically,scaffolds with porosity from 73％ to 85％,pore size from 120 μm to 320 μm and interconnectivity of over 95％ are controllably fabricated at MBG content from 0 wt％ to 20 wt％.In comparison with neat PLGA scaffolds,composite scaffolds perform improved strength (up to 1.5 folds) and Young's modulus (up to 3 folds).The interconnected macroporous structure is beneficial to the ingrowth of cells.More importantly,composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ions.Hopefully,MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological,mechanical and biological features for tissue regeneration.