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丙谷酰胺是较弱的CCK受体拮抗剂。近来,新的丙谷酰胺类似物CR_(1392)、CR_(1409)和CR_(1505)已产生,并且比丙谷酰胺强数白倍。本文作者研究了CR_(1392)抑制作用的可逆性和其毒性,以及对CCK刺激后的离体鼠胰腺腺泡和离体灌注胰腺淀粉酶释放作用。材料和方法:用一只雄性Wistar鼠制备离体胰腺腺泡培养剂是经过改良的重碳酸盐缓冲液和用HE-PES缓冲剂Ringer溶液(HR)。然后进行以下三组研究:第一组检验CR_(1392)抑制CCK-8刺激淀粉酶释放的作用方式。将第二组检验CR_(1392)抑制淀粉酶释放作用的特异性。CCK-8、蛙皮素、氯化氨基、神经介质-C、分泌素、血管肠肽、TPA、A_(23187)、或8 Br-
Progamide is a weaker CCK receptor antagonist. Recently, new allergen CR_ (1392), CR_ (1409), and CR_ (1505) have been generated and are several times stronger than prothiamide. The authors investigated the reversibility and toxicity of CR_ (1392) inhibition and the release of pancreatic amylase from isolated rat pancreatic acinar and CCK-stimulated cells. MATERIALS AND METHODS: Ex vivo pancreatic acinar preparations were prepared from a male Wistar rat modified bicarbonate buffer and HE-PES buffer Ringer solution (HR). The following three groups of studies were then conducted: The first group examined the mode of action of CR 1392 inhibiting the release of amylase by CCK-8. The second panel examined the specificity of CR_ (1392) for inhibiting amylase release. CCK-8, bombesin, ammonium chloride, neuromedin-C, secretin, vasoactive intestinal peptide, TPA, A_ (23187), or 8 Br-