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观察了马钱子碱（Ｂ）和马钱子碱氮氧化物（ＢＮＯ）抗血小板聚集和血栓形成的作用，发现了Ｂ和ＢＮＯ都能显著地抑制由ＡＤＰ和胶原诱导的血小板聚集。与阿斯匹林（ＡＳＰ）比较，在同样终浓度下ＢＮＯ对ＡＤＰ诱导的血小板聚集的抑制作用与ＡＳＰ相似，但对胶原诱导的血小板聚集的抑制作用则强于ＡＳＰ。Ｂ对ＡＤＰ或胶原诱导的血小板的抑制作用均强于ＢＮＯ和ＡＳＰ。Ｂ、ＢＮＯ和ＡＳＰ抗ＡＤＰ诱导的血小板聚集的ＩＤ５０依次为０．８７７，２．３１９和２．０１２ｍｍｏｌ·ｍｌ－１；抗胶原诱导的血小板聚集的ＩＤ５０依次为０．７００，３．９５０，４．１８７ｍｍｏｌ·ｍｌ－１。Ｂ、ＢＮＯ都有类似ＡＳＰ的抗血栓形成作用，血栓抑制率分别为Ｂ：４７．５％、ＢＮＯ：５０．６％和ＡＳＰ：４２．１％。虽然Ｂ的剂量是ＢＮＯ和ＡＳＰ的一半，即有与ＢＮＯ和ＡＳＰ相近的血栓抑制率，但已显示明显的积蓄性毒性。
The effects of strychnine (B) and strychnine nitrogen oxide (BNO) on antiplatelet aggregation and thrombosis were observed. Both B and BNO were found to significantly inhibit platelet aggregation induced by ADP and collagen. Compared with aspirin (ASP), BNO inhibited ADP-induced platelet aggregation at the same final concentration as ASP, but inhibited collagen-induced platelet aggregation more than ASP. The inhibitory effect of B on ADP or collagen-induced platelets was stronger than that of BNO and ASP. The ID50 of anti-ADP induced platelet aggregation by B, BNO and ASP were 0.877,2.319 and 2.012 mmol·ml-1,respectively; the ID50 of collagen-induced platelet aggregation was 0.700,3.950,4 respectively. .187mmol·ml-1. Both B and BNO had antithrombotic effects similar to those of ASP. The thrombolytic inhibition rates were B: 47.5%, BNO: 50.6%, and ASP: 42.1%, respectively. Although the dose of B is half that of BNO and ASP, ie, it has similar thrombolytic inhibition rates as BNO and ASP, it has shown significant accumulation toxicity.