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非药物治疗3～6个月无效时,需进行药物治疗,其目的在于减低中、重度高血压患者有关心血管病的发病率与病死率,以及防止轻度高血压变为中、重度高血压。经过试验,药物治疗确能防止轻度高血压患者发生中风、左室肥大、充血性心力衰竭以及血压发展至严重水平。澳大利亚对舒张压95～109mmHg的高血压患者进行药物治疗,也证明可使心血管病发病率和病死率大幅度下降(与安慰剂组对照)。现尚有争议的问题是舒张压90～94mmHg的患者,如果非药物治疗不能满意地控制高血压,是否一定要用药物治疗?长期药物治疗的副作用会否减低或否定短期治疗的效果。
Non-drug treatment of 3 to 6 months is invalid, the need for drug treatment, which aims to reduce moderate and severe hypertension in patients with cardiovascular disease incidence and mortality, and prevent mild hypertension into moderate to severe hypertension . After testing, drug therapy does prevent stroke, left ventricular hypertrophy, congestive heart failure and blood pressure to severe levels in patients with mild hypertension. Drug therapy in hypertensive patients with a 95-110 mmHg diastolic blood pressure in Australia also demonstrated a significant reduction in cardiovascular morbidity and mortality (compared with placebo). The controversial issue is that patients with diastolic BP of 90-94 mmHg should be treated with medications if they are not satisfactorily controlled by nonpharmacologic therapy. Will side effects of long-term medications reduce or negate the effects of short-term treatment?