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目的:研究毛茛科植物黄连Coptis chinensis Franch的化学成分。方法:利用柱色谱、凝胶柱色谱、高效液相色谱等各种色谱技术对黄连的95%提取物进行分离,根据所得化合物的理化性质与UV,IR,MS,NMR等光谱数据鉴定其结构。结果:从黄连的95%乙醇提取物的三氯甲烷萃取部分分离得到7个已知成分,分别鉴定为巴马亭(1),6,7-mthylenedioxy-1(2H)-isoquinolinone(2),methyl-3-O-quicinate(3),ethyl-4-O-quicinate(4),邻二苯酚(5),2,3-bis[(4-hydroxy-3,5-dimethxyphenyl)-methyl]-1,4-butanediol(6),dihydro-dehydrodiconiferyl alcohol(7)。结论:化合物3,4为首次从黄连中分离得到,化合物6,7为首次从该属植物中分离得到。
Objective: To study the chemical constituents of Coptis chinensis Franch from Ranunculaceae. Methods: 95% extracts of Coptis chinensis Franch were separated by column chromatography, gel column chromatography and high performance liquid chromatography. The structures of the compounds were identified by their physicochemical properties and UV, IR, MS, NMR and other spectroscopic data . Results: Seven known components were isolated from the chloroform extract of 95% ethanol extract of Coptis chinensis Franch. They were identified as palmatine (1), 6,7-mthylenedioxy-1 (2H) -isoquinolinone ethyl-4-O-quicinate (4), 2,3-bis [(4-hydroxy-3,5-dimethoxyphenyl) -methyl] 1,4-butanediol (6), dihydro-dehydrodiconiferyl alcohol (7). Conclusion: Compounds 3 and 4 were isolated from Coptis chinensis for the first time. Compounds 6 and 7 were isolated from this genus for the first time.