用亚硝酸盐法和原子吸收法分别测定了食管上皮细胞正常、轻度增生、重度增生人群及食管癌患者的血清ＣｕＺｎＳＯＤ水平及参与其活性中心构成的Ｃｕ的含量。结果显示：随食管上皮病变的进展，血清ＣｕＺｎＳＯＤ及Ｃｕ含量均逐渐增加，表明食管癌发病过程中伴有抗氧化能力的代偿性增加。血清ＣｕＺｎＳＯＤ与Ｃｕ含量之间亦均呈现一定的正相关性，提示ＣｕＺｎＳＯＤ测定亦可作为机体Ｃｕ营养的指示指标之一 The levels of serum CuZnSOD in the esophageal epithelial cells in normal, mildly hyperplastic, hyperplastic patients and esophageal cancer patients were measured by nitrite method and atomic absorption method. The content of Cu in the active centers was also measured. The results showed that with the progress of esophageal epithelial lesions, serum CuZnSOD and Cu content were gradually increased, indicating that compensatory increase in antioxidative capacity was associated with the pathogenesis of esophageal cancer. There is also a positive correlation between serum CuZnSOD and Cu content, suggesting that CuZnSOD can also be used as an indicator of Cu nutrition in the body.