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临床和实验均已证实醛固酮对心血管系统有多种毒性作用,在心脏中它已与肾素-血管紧张素共同促成心肌纤维化、血管重塑、心室肥大和动脉硬化等改变,进一步诱发心律失常,加重心肌缺血;在冠心病领域中可作为预测不良事件发生的一个独立指标;在一定程度上反映了心房颤动患者神经激素的激活,并与代谢综合征危险因素密切相关,对心力衰竭进程及预后具有重要的预测价值。而醛固酮受体拮抗剂可以预防或延缓这些不利作用的发生,在心血管系统中将发挥重要作用。
Alzheimer’s disease has been shown clinically and experimentally to have a variety of toxic effects on the cardiovascular system, where it has been combined with renin-angiotensin-induced changes in cardiac fibrosis, vascular remodeling, ventricular hypertrophy and atherosclerosis to further induce cardiac rhythm Disorders, increased myocardial ischemia; in the field of coronary heart disease can be used as an independent predictor of adverse events; to some extent, reflects the activation of neurohormones in patients with atrial fibrillation and metabolic syndrome risk factors are closely related to heart failure Process and prognosis have important predictive value. And aldosterone receptor antagonists can prevent or delay the occurrence of these adverse effects in the cardiovascular system will play an important role.