自Hippocrates年代以来,已知肝病患者有行为异常和意识障碍,但其机理仍未清。脑障碍可能与肝脏不能把维持脑功能的某种必需的物质送入血循环有关,经常考虑的物质是胞嘧啶核甙(Cytidine)和尿嘧啶核甙(Uridine)。然而,在摘除肝脏的大鼠与正常供血者交叉灌流,以脑功能变化作判断,此假说是靠不住的。体—门交叉循环较体—体交叉循环易于引起肝性脑病。如果肝性脑病是由于肝脏产生的某种物质的缺乏,则两种循环应得同等效果。肝性脑病似更可能是由于肝衰后 Since the age of Hippocrates, patients with liver disease are known to have abnormal behavior and disturbance of consciousness, but the mechanism remains unclear. Brain disorders may be related to the inability of the liver to send certain essential substances that maintain brain function into the bloodstream. Cytidine and uridine are often considered. However, this hypothesis is unreliable when cross-perfusion is performed between liver-ablating rats and normal donors, judging from changes in brain function. Body - door cross-cycle more than body-body cross-circulation prone to cause hepatic encephalopathy. If hepatic encephalopathy is due to lack of a substance produced by the liver, both cycles should be equally effective. Hepatic encephalopathy is more likely due to liver failure