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目的 :研究乳腺癌患者外周血hMAMmRNA检测临床应用价值。方法 :应用逆转录聚合酶联反应 (RT PCR)技术检测了 97例乳腺癌患者外周血hMAMmRNA ,观察其与临床病理参数的关系 ,化疗前后外周血hMAMmRNA的变化。结果 :肿瘤原发灶 >2cm和≤ 2cm两组间、淋巴结有无转移两组间、有无远处转移两组间hMAMmRNA阳性表达率差异有统计学意义 ;hMAMmRNA阳性组化疗前后肿瘤缩小 ,差异有统计学意义。结论 :外周血hMAMmRNA阳性率可以反映乳腺癌的病期 ,外周血hMAMmRNA表达的变化可以反映化疗效果。HMAMmRNA表达的检测对乳腺癌转移患者预后、治疗方案的评估具一定的意义
Objective: To study the clinical value of detecting hMAM mRNA in peripheral blood of breast cancer patients. Methods: The hMAM mRNA in peripheral blood of 97 patients with breast cancer was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). The relationship between hMAM mRNA and clinicopathological parameters was observed. The changes of hMAM mRNA in peripheral blood before and after chemotherapy were also observed. Results: There was significant difference of hMAM mRNA expression between the two groups in the primary tumor> 2cm and ≤ 2cm, lymph node metastasis, with or without distant metastasis. The tumor size of the hMAMmRNA positive group was decreased before and after chemotherapy There is statistical significance. Conclusion: The positive rate of hMAM mRNA in peripheral blood can reflect the disease stage of breast cancer. The change of hMAM mRNA expression in peripheral blood can reflect the effect of chemotherapy. Detection of HMAM mRNA expression in patients with breast cancer metastasis prognosis, the evaluation of treatment programs of some significance