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目的探明胃粘膜良性病变和恶性病变之间的关系。方法应用免疫组化S—P法，检测胃粘膜结肠型和小肠型化生及轻度不典型增生和中重度不典型增生细胞中P53、P21、P16、EGFR、PCNA和CEA的表达，并和胃癌组织及正常冒粘膜组织进行对照。结果P21对判断细胞的癌变倾向有帮助，而P53仅在癌组织内才有明显表达，P16在良性病变和癌组织内的表达与理论上有出入，EGFR在胃癌及中重度不典型增生有明显表达，结肠型化生次之，小肠型化生及正常胃粘膜几无表达，CEA及PCNA在两型肠化生及各类不典型增生中的表达无显著差异。结论胃粘膜结肠型化生及中重度不典型增生较其他良性病变更易发生恶性转化。
Objective To explore the relationship between benign and malignant lesions of gastric mucosa. Methods The expressions of P53, P21, P16, EGFR, PCNA and CEA were detected by immunohistochemical S-P method in colonic and small intestine, mild atypical hyperplasia and moderate to severe dysplasia, Gastric cancer tissues and normal mucosa tissue control. Results P21 was helpful to judge the canceration tendency of cells, while P53 was only expressed in cancerous tissues. The expression of P16 in benign lesions and cancerous tissues was different from that in theory. The expression of EGFR in gastric cancer and moderate to severe atypical hyperplasia was significant There was no significant difference in the expression of CEA and PCNA between the two types of intestinal metaplasia and all kinds of atypical hyperplasia. Conclusions Gastric mucosal colon hyperplasia and moderate to severe atypical hyperplasia are more likely to malignant transformation than other benign lesions.