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目的 :了解流行性出血热病毒 ( EHFV)对肝脏的损害及肝功能的影响.方法 :对 5 6例流行性出血热( EHF)患者的肝功能及乙型肝炎病毒 ( HBV )标记物的检测结果进行分析.结果 :14 9例 ( 88%)出现 AL T和 AST升高 ,其中有 2 3例 ( 4 1%)伴有血清总胆红素 ( STB)升高 ;2 2 6例重型和危重型病人中 ,发生重度肝损害 10例 ,占全部重度肝损害的 83%. 3 5 1例进行 HBV标记物检测 ,发现 HBV感染 2 4例 ,EHFV重叠 HBV感染率为 4 7%;单纯感染组与重叠感染组的肝损害情况比较 ,重叠感染组的 AL T比单纯感染组显著升高 ( P0 .0 5 ).结论 :1EHF并发肝损害较普遍 ,病情重者发生肝损害的程度也严重 ;2 EHF重叠 HBV感染也较多见 ,但重叠 HBV感染者中的肝损害的发生率及黄疸的程度并无明显升高.“,”Objective: To investigate the liver lesion and changes of liver function in epidemic hemorrhagic fever virus(EHFV) Methods:A retrospective analysis on the laboratory tests of liver function and hepatitis B virus markers in 56 cases with epidemic hemorrhagic fever (EHF) was carried out Results:① Elevated serum alanine aminotransfe rases (ALT) and aspartate aminotransferases (AST) were observed in 49 cases (88%),of which 23 cases (41%) had elevated serum total bilirubin (STB) ②Severe liver lesion was found in 10 of 26 severe cases ③In cases who had HBV markers tests,the results showed that 24 out of 51 cases were infected by HBV The rate of superinfection was 47% ALT level was significantly higher in the superinfection group than in the group of cases infected by EHFV only( P 0 05) Conclusion:①The liver lesion is commonly observed in EHF,the more severe the disease,the more severe the liver lesion ②HBV superinfection is commonly observed in cases of EHF,but the rate of occurrence of liver lesion and STB index in the superinfection cases seem to be not significantly high