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探讨胰岛素样生长因子 1受体 (IGF 1R)过度表达与乳腺癌术后、放射治疗后复发的相关性。方法 回顾性研究 2 5例乳腺癌术后、放射治疗后复发的病例 (复发组 ) ,同时设对照组5 0例。采用免疫组织化学的方法测定肿瘤组织的IGF 1R表达情况 ,分为 -、+、+ +、+ + + ,并将+ +和 + + +定义为过度表达。结果 复发组的过度表达率明显高于对照组 ,分别为 76 % ,2 2 % ,二者差异有极显著意义 (P <0 .0 1)。IGF 1R的表达与肿瘤大小、淋巴结转移情况、TNM分期无明显相关性。在全部病例中 ,IGF 1R过度表达者的 3、5年生存率显著降低 (P =0 .0 0 0 3) ;但在复发组中进一步分析生存情况 ,结果并未发现IGF 1R过度表达对生存有显著影响 (P =0 .5 5 10 )。结论 本研究从临床方面初步证实了IGF 1R与乳腺癌术后、放射治疗后复发的相关性 ;提示IGF 1R过度表达与乳腺癌细胞的放射抗拒有关 ,可能是一个预测放射敏感性的重要指标。
To investigate the relationship between overexpression of insulin-like growth factor 1 receptor (IGF 1R) and recurrence after breast cancer surgery and radiation therapy. Methods A retrospective study of 25 cases of postoperative recurrence of breast cancer and radiation therapy (recurrence group) and 50 cases of control group. The expression of IGF 1R in tumor tissues was determined by immunohistochemistry and divided into -, +, + +, + + +, and + + and + + + were defined as overexpression. Results The overexpression rate of the recurrent group was significantly higher than that of the control group, which was 76% and 2% respectively. The difference between the two groups was extremely significant (P < 0.01). There was no significant correlation between the expression of IGF 1R and tumor size, lymph node metastasis, and TNM stage. In all cases, the 3- and 5-year survival rates of IGF-1R overexpression were significantly lower (P=0.030); however, survival was further analyzed in the relapsed group, and IGF-1R overexpression was not found to be effective for survival. There was a significant effect (P = 0.55 10). Conclusion This study has initially confirmed the correlation between IGF 1R and postoperative breast cancer recurrence after radiotherapy, suggesting that overexpression of IGF 1R is associated with radioresistance of breast cancer cells and may be an important predictor of radiosensitivity.