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引言药物代谢动力学(下简称药代动力学)作为一门学科近十年来有飞跃的发展,教材中对其计算与应用已有论著。利用药物代谢动力学的概念和模型有助于针对不同病情实施个体给药方案现已较普遍,但药代动力学对药物设计的效果还刚刚开始认识。最近召开的专题讨论会集中讨论了通过前体药物及其类似物,设计具有生物药剂特性药物的若干方法。药物设计中应用药代动力学是鉴于这样的事实,即某些药物之所以缺乏最适宜的或合乎要求的治疗活性,不是因药物-受体间的相互作用不充分,而是由于药物到达受体时的浓度和/
Introduction Pharmacokinetics (hereinafter referred to as pharmacokinetics) as a discipline has leaps and bounds in the past decade, textbooks have been on the calculation and application of the treatise. The use of pharmacokinetic concepts and models to aid in the administration of individual dosing regimens to different conditions is now common, but the effects of pharmacokinetics on drug design are just beginning to be recognized. The recent symposium focused on the design of several approaches for the design of drugs with biopharmaceutical properties through prodrugs and their analogues. Pharmacokinetics in drug design is due to the fact that certain drugs lack the most appropriate or desirable therapeutic activity not because of inadequate drug-receptor interactions but because drug arrival Body concentration and /