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目的:探讨玉女煎联合胰岛素泵短期强化干预对妊娠期糖尿病患者血糖及妊娠结局的影响。方法:选择妊娠期糖尿病患者为研究对象,在患者知情自愿的条件下,随机分为治疗组和对照组。对照组采用胰岛素泵进行治疗,治疗组在对照组基础上给予中药汤剂玉女煎。治疗两周后,分析比较两组患者治疗前后血糖控制情况、血脂含量以及妊娠结局。结果:治疗组总有效率为93.0%,对照组为67.4%,治疗组优于对照组(P<0.05);两组治疗后空腹血糖、餐后2 h血糖以及糖化血红蛋白均显著降低(P<0.05),治疗组治疗后空腹血糖、餐后2 h血糖以及糖化血红蛋白均显著低于对照组治疗后(P<0.05);两组治疗后TC、TG、LDL-C均显著降低(P<0.05),而HDL-C治疗后均出现显著升高(P<0.05),治疗组治疗后TC、TG、LDL-C均显著低于对照组(P<0.05),而HDL-C显著高于对照组(P<0.05);治疗组孕妇剖宫产、羊水异常以及胎膜早破发生率均显著低于对照组(P<0.05),治疗组新生儿窒息、胎儿窘迫以及早产发生率均显著低于对照组(P<0.05)。结论:玉女煎联合胰岛素泵短期治疗妊娠期糖尿病,能够快速有效的控制血糖,改善妊娠结局。
Objective: To investigate the effect of jade female fried insulin pump short-term intensive intervention on blood glucose and pregnancy outcome in patients with gestational diabetes mellitus. Methods: Patients with gestational diabetes mellitus were selected as research subjects and randomly divided into treatment group and control group under informed and voluntary conditions. Control group with insulin pump for treatment, the treatment group in the control group on the basis of Chinese medicine decoction jade fried. After two weeks of treatment, the blood sugar control, blood lipid level and pregnancy outcome were analyzed and compared before and after treatment. Results: The total effective rate was 93.0% in the treatment group and 67.4% in the control group, the treatment group was superior to the control group (P <0.05). The fasting blood glucose, postprandial 2-hour postprandial blood glucose and glycosylated hemoglobin were significantly decreased in both groups (P < 0.05). After treatment, fasting blood glucose, postprandial blood glucose and HbA1c in the treatment group were significantly lower than those in the control group after treatment (P <0.05); TC, TG and LDL-C in the two groups were significantly decreased after treatment (P <0.05). After treatment, the levels of TC, TG and LDL-C in the treatment group were significantly lower than those in the control group (P <0.05), while the levels of HDL-C in the treatment group were significantly higher than those in the control group (P <0.05). The incidences of cesarean section, amniotic fluid abnormalities and premature rupture of membranes in pregnant women in the treatment group were significantly lower than those in the control group (P <0.05). The incidence of neonatal asphyxia, fetal distress and preterm birth were significantly lower in the treatment group In the control group (P <0.05). Conclusion: Jade combined with insulin pump short-term treatment of gestational diabetes mellitus, can quickly and effectively control blood sugar, improve pregnancy outcome.