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材料和方法:研究对象为145例接受维持量毛地黄制剂的各种心脏病患者。男75例,女70例。年龄16～93岁(平均57.3岁)。61例患缺血性心脏病及高血压性心脏病,84例患先天性心脏病及瓣膜性心脏病。59例给予洋地黄毒甙(每日0.05～0.075～0.15毫克),86例给予狄戈辛(每日0.125～0.1875～0.375毫克)。除毛地黄浓度外,还同时测定血清白蛋白、肌酐、尿素氮、电解质(钠、钾.钙.镁)、SGOT、SGPT。并作了心电图和胸部X片检查。为了检查血清毛地黄浓度的时间过程,对用维持量毛地黄进行治疗的7例患者,在服药前和服药后1、2,4、6、8、12和24小时抽取血标本。另外在20例患者中,于不同日期多次测量药物血清浓度以观察
MATERIALS AND METHODS: A total of 145 patients with various heart diseases receiving maintenance dose of rhG alone were enrolled. 75 males and 70 females. Age 16 to 93 years (mean 57.3 years old). 61 cases of ischemic heart disease and hypertensive heart disease, 84 cases of congenital heart disease and valvular heart disease. Fifty-nine patients were given digoxin (0.05-0.075-0.15 mg daily) and 86 patients were given Digoxin (0.125-0.1875-0.375 mg daily). In addition to the concentration of hairy yellow, but also simultaneous determination of serum albumin, creatinine, urea nitrogen, electrolytes (sodium, potassium calcium, magnesium), SGOT, SGPT. And made a cardiogram and chest X-ray examination. In order to examine the time course of the concentration of hirsutum in blood, blood samples were taken before and 7 days, 1, 2, 4, 6, 8, 12 and 24 hours after treatment with maintenance dose of foxglove. In addition, in 20 patients, drug serum concentrations were measured repeatedly on different days for observation