论文部分内容阅读
目的：研究抑癌基因P53在舌癌及癌前病变中的表达。方法：采用免疫组化技术对正常舌粘膜，单纯性上皮增生，轻、中、重度不典型增生，以及舌鳞疾进行了抑癌基因P53表达相关分析。结果：正常舌粘膜基底细胞中偶见阳性细胞（2／5）；单纯性上皮增生中基底层细胞阳性率增加（3／5）；轻、中、重度不典型增生P53阳性细胞逐渐增多（阳性率分别为6O％，80％，80％）；舌鳞癌阳性率为80％（20／25）。结论：P53过度表达与舌癌的发生关系密切。
Objective: To study the expression of tumor suppressor gene P53 in tongue cancer and precancerous lesions. Methods: Immunohistochemical technique was used to analyze the expression of anti-oncogene P53 in normal tongue mucosa, simple epithelial hyperplasia, mild, moderate and severe dysplasia, and tongue squamous cell carcinoma. Results: Positive cells in basal cells of normal tongue mucosa were occasionally seen (2/5); the positive rate of basal cells in simple epithelial hyperplasia increased (3/5); the number of P53 positive cells in mild, moderate and severe atypical hyperplasia increased Rates were 6O%, 80%, 80%); tongue squamous cell carcinoma positive rate was 80% (20/25). Conclusion: P53 overexpression is closely related to the occurrence of tongue cancer.