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在体外循环中,肝素抗凝,以及体外循环结束时用鱼精蛋白中和肝索,其合适的程度非常重要,抗凝不够可引起微栓或栓块形成,而鱼精蛋白量若不够,术后可引起出血,两者过量亦均可引起凝血机制障碍,抗凝和中和的方案很多,过去大都以体重或体表面积计算使用肝素剂量,过一定时间后,追加一定的量.鱼精蛋白用量.则一般与肝索用量按比例应用,1:1至1:1.5不等。 但对肝素的敏感性及其清除率在体外循环下每人变异很大,可有3～4倍之差,并且难以照病人年龄、体重,体表面积来预测.肝素的需要量亦受尿排出量的影响。为了避免体外循环中形成微栓,栓块,以及在结束时用鱼精蛋白中和得适宜,需有一
In extracorporeal circulation, heparin anticoagulation, and the end of extracorporeal circulation with protamine and hepatic cord, its appropriate degree is very important, insufficient anticoagulation can cause micro-plug or block formation, and the protamine amount is not enough, After surgery can cause bleeding, both excessive also cause coagulation disorders, anticoagulation and neutralization of many programs, most of the past weight or body surface area calculated using heparin dose, after a certain period of time, add a certain amount. Protein dosage is generally used in proportion to the amount of hepatic cord, 1: 1 to 1: 1.5 range. However, the sensitivity to heparin and clearance rate per person under cardiopulmonary bypass varies widely, can be 3 to 4 times the difference, and difficult to predict according to age, weight, body surface area of patients. The impact of volume. In order to avoid the formation of microthrombi in the cardiopulmonary bypass, plug, and in the end with protamine and appropriate, there must be a