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提要人乳头状瘤病毒18型E6E7AAV感染胎儿食管，建立一株新的人食管，上皮细胞株（SHEE），这株细胞成为永生化并继续繁殖超过60代。经过长时间的传代培养，其10代细胞表型保留原始上皮细胞培养物的特征，表现为单层生长和锚使依赖性生长，在软琼脂培养不形成克隆，接种裸鼠未成
Abstract Human papillomavirus type 18 E6E7AAV infects the fetal esophagus and establishes a new human esophageal and epithelial cell line (SHEE) that becomes immortalized and continues to breed for more than 60 generations. After a long period of subculture, the 10-generation cell phenotype retained the characteristics of the original epithelial cell culture, showing monolayer growth and anchorage-dependent growth, did not form colonies in soft agar and did not inoculate nude mice