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目的探讨实时光电探测系统(Truscreen Cervical Cancer Screening system,TS)与人乳头瘤病毒检测(Human papilloma virus,HPV)在液基薄层细胞学检测(Thinprep-liquid-based cytological test,TCT)提示意义不明的不典型鳞状上皮细胞(Atypical squamous cells of undetermined significance,ASCUS)中的诊断效果对比。方法对于243例TCT提示ASCUS的病例,以阴道镜下病理学结果为金标准,比较TS及HPV的灵敏度、特异度及ROC(Receiver operator characteristic curve,ROC)曲线下面积。结果 243例病例中,TS、HPV的灵敏度分别为74.2%、47.6%,特异度分别为77.6%、84.9%;比较ROC曲线下面积,TS与HPV差异有统计学意义(P<0.05)。结论本研究中,对于TCT提示ASCUS的病例,TS的诊断效果优于HPV,临床上可考虑用TS作为对细胞学提示ASCUS病例的确认检测方法之一。
Objective To investigate the significance of the detection of human papilloma virus (HPV) by the ThinPrep-liquid-based cytological test (TCT) by the Truscreen Cervical Cancer Screening System (TSTC) Of atypical squamous cells (Atypical squamous cells of undetermined significance, ASCUS) in the diagnosis of contrast effect. Methods The sensitivity and specificity of TS and HPV and the area under curve of receiver operating characteristic curve (ROC) were compared between 243 cases of ASCUS with ASCUS and colposcopy pathology as the gold standard. Results The sensitivity of TS and HPV were 74.2% and 47.6% respectively, and the specificity were 77.6% and 84.9% respectively. The area under ROC curve was significantly different between TS and HPV (P <0.05). Conclusions In this study, the diagnosis of ASCUS was superior to that of HPV in cases of TCT-hint ASCUS, and TS may be considered clinically as one of the confirmatory tests for ASCUS cases of cytology.