目的：探讨氟罗沙星与氧氟沙星治疗急性细菌感染的疗效情况。方法：采用随机对照方法，应用氟罗沙星治疗各种急性细菌感染５２例，并与５１例应用氧氟沙星治疗的患者作比较。结果：氟罗沙星组的痊愈率为７３１％、有效率为９４２％、细菌阴转率为９２２％、细菌消除率为９２２％；氧氟沙星组则分别为５６９％、８６３％、８７２％、８７５％，两组比较，差异无显著性意义（Ｐ＞００５）。氟罗沙星的不良反应发生率为８／５２（１５４％），略高于对照组（１３８％），不良反应以消化系统和中枢神经系统症状多见，程度较轻，不需特殊处理，对肝、肾、血液系统亦无明显毒性作用。结论：氟罗沙星的疗效及不良反应与氧氟沙星相近似。 Objective: To investigate the efficacy of fleroxacin and ofloxacin in the treatment of acute bacterial infections. Methods: A randomized controlled trial of fleroxacin was used to treat various acute bacterial infections in 52 patients and compared with 51 patients treated with ofloxacin. Results: The cure rate of fleroxacin group was 731%, the effective rate was 942%, the bacterial negative conversion rate was 922%, the bacterial elimination rate was 922%, while the ofloxacin group was 56  9%, 863%, 872% and 875%, respectively. There was no significant difference between the two groups (P> 005). The incidence of adverse reactions of fleroxacin was 8/52 (154%), slightly higher than that of the control group (138%). Adverse reactions were more common in the digestive system and central nervous system, with less severity Treatment, the liver, kidney, blood system also had no significant toxic effects. Conclusion: The efficacy and adverse reactions of fleroxacin are similar to ofloxacin.