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目的探讨肺表面活性物质联合机械通气辅助治疗新生儿肺透明膜病的临床疗效。方法选取2011年3月~2013年3月简阳市人民医院就诊的新生儿肺透明膜病患者132例,在常规综合治疗的基础上采用表面活性物质(珂立苏)联合机械通气辅助治疗,通过患儿临床症状改善情况和治疗前后血气分析参数、机械通气参数对比分析结果,判断该法的临床疗效。结果治疗后患儿的临床症状改善明显,生命体征平稳。治疗后2h、6h、12h的PaO2、SaO2、PaCO2、pH和治疗前比较差异有统计学意义(P<0.05);治疗后2h、6h、12h的FiO2、PIP、PEEP、RR和治疗前比较差异有统计学意义(P<0.05)。结论肺表面活性物质联合机械通气辅助治疗新生儿肺透明膜病的临床疗效显著,是治疗该类疾病的一种可靠方法。
Objective To investigate the clinical efficacy of pulmonary surfactant combined with mechanical ventilation in the treatment of neonatal hyaline membrane disease. Methods A total of 132 neonates with hyaline membrane disease from March 2011 to March 2013 in Jianyang People’s Hospital were selected and treated with the combination of surfactant (Ke Li Su) and mechanical ventilation on the basis of conventional comprehensive treatment. Children with improvement of clinical symptoms and blood gas analysis before and after treatment parameters, mechanical ventilation parameters comparative analysis of the results to determine the clinical efficacy of the law. Results After treatment, the clinical symptoms of children improved significantly, and vital signs were stable. PaO2, SaO2, PaCO2, pH of 2h, 6h, 12h after treatment were significantly different from those before treatment (P <0.05); FiO2, PIP, PEEP, RR at 2h, There was statistical significance (P <0.05). Conclusion The combination of pulmonary surfactant with mechanical ventilation in the treatment of neonatal hyaline membrane disease has a significant clinical effect and is a reliable method for the treatment of such diseases.