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目前发现,促血栓形成性基因变异可能促进阿司匹林抵抗,增加心血管事件的风险。这些基因多态性主要包括:①编码环氧合酶1的基因多态性;②编码血小板膜糖蛋白Ⅲa的血小板抗原1/血小板抗原2多态性;③编码血小板膜糖蛋白Ⅰa/Ⅱa的807C/T和873G/A多态性。通过基因多态性的检测不仅有助于阐明阿司匹林抵抗的发生机制,同时也为患者选择合理有效的药物疗法、实现治疗策略的个体化以及临床转归的评估提供理论基础。
It has been found that the promotion of thrombotic gene mutation may promote aspirin resistance and increase the risk of cardiovascular events. These gene polymorphisms include: ① gene polymorphism encoding cyclooxygenase 1; ② platelet antigen 1 / platelet antigen 2 polymorphism encoding platelet membrane glycoprotein Ⅲa; ③ gene encoding platelet membrane glycoprotein Ⅰ a / Ⅱ a 807C / T and 873G / A polymorphisms. The detection of gene polymorphism not only helps clarify the mechanism of aspirin resistance, but also provides a theoretical basis for patients to choose reasonable and effective drug therapy, individualized treatment strategies and evaluation of clinical outcome.