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目的评价曲美他嗪联合常规药物疗法对老年不稳定性心绞痛(UAG)的临床疗效。方法72例UAG患者随机分为2组,对照组:采用常规治疗方法:抗血小板药物、抗凝药物、β受体阻滞剂、硝酸酯类、钙离子阻滞剂、血管紧张素转换酶抑制剂及调脂药物治疗;治疗组:在对照组治疗的基础上,加用曲美他嗪治疗4周。观察2组患者临床症状改善、治疗前后心电图变化以及硝酸酯类用量变化。结果与对照组比较,治疗组在ST段下降幅度、总缺血发作时间、缺血发作次数、硝酸酯类用量减少等方面都有显著性差异(P<0.05)。结论曲美他嗪可改善老年不稳定性心绞痛的临床症状,是常规治疗方法以外的一种新选择。
Objective To evaluate the clinical efficacy of trimetazidine combined with conventional drug therapy in elderly patients with unstable angina pectoris (UAG). Methods 72 patients with UAG were randomly divided into two groups. The control group was treated with conventional therapy: antiplatelet drugs, anticoagulants, β blockers, nitrates, calcium blockers, angiotensin converting enzyme Agents and lipid-lowering drug treatment; treatment group: in the control group based on the treatment, plus trimetazidine treatment for 4 weeks. Two groups of patients were observed to improve clinical symptoms, ECG changes before and after treatment and nitrate dosage changes. Results Compared with the control group, the treatment group had significant differences (P <0.05) in the range of ST segment decline, the total ischemic attack time, the number of ischemic attacks and the reduction of nitrate dosage. Conclusion Trimetazidine can improve the clinical symptoms of unstable angina in elderly patients, which is a new alternative to conventional treatment.