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本文以肺癌患者的外周血为材料,进行了其染色体的不稳定性和脆性部位的分析。实验组血液样本从11位肺癌患者身上取得,正常对照血液从7位健康人身上取得,一级亲属对照的血样取自于7位健康的一级亲属。外周血淋巴细胞在37℃的条件下,于Tc199培养基中培养96小时。利用常规法和G显带技术制备染色体标本,镜检分析。结果表时患者与正常人之间有显著性差异,但一级亲属与正常人及患者之间无差异。
In this paper, the peripheral blood of patients with lung cancer was used as material to analyze the chromosome instability and fragility. Blood samples from the experimental group were obtained from 11 lung cancer patients, normal control blood was obtained from 7 healthy persons, and blood samples from the first-degree relatives were taken from 7 healthy first-degree relatives. Peripheral blood lymphocytes were cultured in Tc199 medium for 96 hours at 37°C. Chromosomal specimens were prepared using conventional methods and G-banding techniques and examined by microscopy. There was a significant difference between the patient and the normal person in the results table, but there was no difference between the first-degree relatives and normal persons and patients.