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观察氨氯地平与卡托普利对顽固性高血压的联合治疗作用。方法高血压Ⅱ～Ⅲ期病人４２人，入选前停药两周，经卡托普利１２．５ｍｇ３／ｄ，２周后ＤＢＰ＞９５ｍｍＨｇ者随机分成２组，分别加服氨氯地平和安慰剂，４周为一个疗程。结果在卡托普利基础上加服氨氯地平使平均ＳＢＰ从１７４降至１４８ｍｍＨｇ。平均ＤＢＰ从１０５降至９２ｍｍＨｇ（Ｐ＜０．００１），安慰剂纠正的氨氯地平降压作用ＳＢＰ降低２２ｍｍＨｇ，ＤＢＰ降低１２ｍｍＨｇ（Ｐ＜０．０１）。结论氨氯地平与卡托普利合用可用于治疗顽固性高血压。
To observe the combination therapy of amlodipine and captopril on refractory hypertension. METHODS: Forty-two patients with stage II-III hypertension were enrolled and were discontinued for two weeks prior to enrollment. Patients were randomized into two groups with captopril 12.5 mg / d and DBP> 95 mm Hg after 2 weeks. Amlodipine and placebo , 4 weeks for a course of treatment. Results Adding caprotol along with amlodipine reduced the average SBP from 174 to 148 mmHg. Mean DBP decreased from 105 to 92 mmHg (P <0.001), placebo-corrected amlodipine SBP decreased 22 mmHg, and DBP decreased 12 mmHg (P <0.01). Conclusion Amlodipine combined with captopril can be used to treat refractory hypertension.