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目的:观察冠心病患者冠脉支架植入前后,血清白细胞介素18(IL-18)及C反应蛋白(CRP)水平的变化。方法:冠心病患者30例在冠脉支架植入前后,分别于空腹12 h后清晨采集静脉血5 ml。采用双抗体夹心ELISA法测定外周血清IL-18的浓度,选用全自动生化分析仪测定CRP的含量,并比较冠脉支架植入术前后IL-18和CRP水平的变化。结果:冠脉支架植入术前,血清IL-18的平均浓度为(1.42±0.47)ng/L,术后平均浓度为(2.64±0.54)ng/L,两者比较差异具有显著性(P<0.01)。术前血清CRP的平均浓度为(5.26±1.28)mg/L,术后平均浓度为(11.86±1.61)mg/L,两者比较差异也具有显著性(P<0.01)。结论:冠脉支架植入术对血清IL-18及CRP的水平有明显影响。
Objective: To observe the changes of serum interleukin 18 (IL-18) and C-reactive protein (CRP) before and after coronary stent implantation in patients with coronary heart disease. Methods: 30 patients with coronary heart disease before and after coronary stent implantation, respectively, in the early morning fasting 12 h after the collection of 5 ml of venous blood. The concentration of IL-18 in peripheral blood was measured by double antibody sandwich ELISA. The contents of CRP in serum were determined by automatic biochemical analyzer. The levels of IL-18 and CRP before and after coronary stenting were compared. Results: Before coronary stent implantation, the average serum concentration of IL-18 was (1.42 ± 0.47) ng / L and the average postoperative mean concentration was (2.64 ± 0.54) ng / L, P < <0.01). The average preoperative serum CRP level was (5.26 ± 1.28) mg / L, and the average postoperative mean concentration was (11.86 ± 1.61) mg / L. There was also significant difference between the two groups (P <0.01). Conclusion: Coronary stenting has a significant effect on serum levels of IL-18 and CRP.