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先前关于硝酸甘油扩张支气管作用的研究已产生了不同的结果,作者认为硝酸盐支气管扩张作用困其使支气管血管舒张引起支气管壁充血,因而影响了通过松弛支气管平滑肌增加呼吸遭通畅的程度。为了验证这一假设,进行了一次随机双盲安慰剂对照交叉试验,对一组吸入血管收缩剂(去甲肾上腺素)预处理的哮喘患者评定了吸入硝酸甘油的支气管扩张作用。 方法 12例(男6、女6例,年龄19～67岁)中度
Earlier studies on the role of nitroglycerin in expanding bronchial tubes have produced differing results. The authors concluded that the bronchodilator bronchodilatation caused by bronchial dilation contributes to bronchial wall hyperemia, thereby affecting the degree to which breathing is smoothed by relaxing the bronchial smooth muscle. To test this hypothesis, a randomized double-blind placebo-controlled crossover study was conducted to assess the bronchodilator effect of inhaled nitroglycerin in a group of asthmatic patients pre-treated with vasoconstrictor (norepinephrine) inhalation. Methods 12 cases (6 males and 6 females, aged 19 to 67 years) were moderate