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目的:了解抗病毒药致不良反应发生的特点及一般规律。方法:检索维普中文科技期刊数据库及中国知网(CNKI)中文期刊全文数据库,收集1999～2009年国内医药学术期刊报道的符合要求的抗病毒药致不良反应文献52篇,共523例,并进行统计、分析。结果:抗病毒药致不良反应中,静脉滴注给药比例最高(82.79%);临床表现复杂多样,主要表现为变态反应、消化系统损害、循环系统损害、泌尿系统损害等,其中,阿昔洛韦以泌尿系统损害最为突出(73例)。结论:临床应重视抗病毒药致不良反应,尤其是过敏性休克,坚持合理用药。
Objective: To understand the characteristics and general rules of antiviral drug-induced adverse reactions. Methods: Fifty-two articles (523 articles) of adverse drug reactions of antiviral drugs that meet the requirements reported in domestic medical academic journals collected from 1999 to 2009 were collected and searched from VIP Chinese Journal of Science and Technology Database and CNKI Chinese Journal Full-text Database Statistical Analysis. Results: Among the adverse reactions caused by antiviral drugs, the highest proportion was given by intravenous drip (82.79%). The clinical manifestations were complex and varied. The main symptoms were allergic reaction, digestive system damage, circulatory system damage and urinary system damage. Among them, Lowell was the most prominent urinary system damage (73 cases). Conclusion: Clinical should pay attention to the adverse reactions caused by antiviral drugs, especially anaphylactic shock, insist on rational drug use.