目的观察不同类型脑梗死患者急性期血清C反应蛋白(C-reactive protein,CRP)的水平,探讨其与TOAST分型的关系。方法对在我院神经科住院的首次发病且发病时间在48h内的202例脑梗死患者进行血清CRP水平的测定,按TOAST分型将脑梗死患者分为大动脉粥样硬化性脑梗死(LAA)组、小动脉闭塞性脑梗死(SAO)组、心源性脑梗死(CE)组、其他病因明确性脑梗死(OC)组、不明病因性脑梗死(UND)组,并进行统计学分析。结果 CE组CRP水平明显高于其他各组,其余各组中,除LAA组明显高于SAO组外,CRP水平差异无统计学意义。结论脑梗死急性期CRP水平对TOAST分型的提示作用有限,在较高水平时提示心源性梗死的可能性大,但仍需进一步的研究。 Objective To observe the level of serum C-reactive protein (CRP) in patients with different types of cerebral infarction in acute stage and to explore its relationship with TOAST classification. Methods Serum CRP levels were measured in 202 patients with cerebral infarction who were first hospitalized in our department of neurology and within 48 hours of onset. According to TOAST classification, patients with cerebral infarction were divided into two groups: aortic atherosclerosis infarction (LAA) (SAO group), cardioembolic infarction (CE) group, other causes of definite cerebral infarction (OC) and unknown etiology of cerebral infarction (UND) group, and statistical analysis was performed. Results The level of CRP in CE group was significantly higher than that in other groups. There was no significant difference in CRP level between the other groups except LAA group and SAO group. Conclusions The acute stage of cerebral infarction CRP levels TOAPT type prompted a limited role in the higher level of the possibility of cardiac infarction, but still need further study.