论文部分内容阅读
目的评估单纯餐后高血糖型糖尿病(IPH)的胰岛素分泌与敏感性的特征,并进一步探讨进展为IPH的相关因素。方法850例受试者按75 g葡萄糖耐量试验分为:糖耐量正常(NGT)557例;单纯糖耐量异常(iIGT)146例;IPH 147例。比较各组的代谢指标及胰岛素分泌和胰岛素敏感性指数。结果早期相胰岛素分泌和胰岛素敏感性指数从NGT→iIGT→IPH逐渐降低,校正年龄和BM I后差异有统计学意义(P<0.05)。对iIGT和IPH患者作线性回归分析显示早期相胰岛素分泌和胰岛素敏感性指数与2hBG密切相关。结论初发的IPH有显著的早期相胰岛素分泌缺陷和胰岛素敏感性降低。β细胞胰岛素分泌缺陷和胰岛素抵抗均是从NGT→iIGT→IPH的进展过程中的决定因素。
Objective To evaluate the characteristics of insulin secretion and sensitivity in simple postprandial hyperglycemic type of diabetes mellitus (IPH) and to further explore the related factors of progression to IPH. Methods 850 patients were divided into 757 glucose tolerance test: 557 cases of normal glucose tolerance (NGT); 146 cases of simple impaired glucose tolerance (iIGT); 147 cases of IPH. Metabolic parameters and insulin secretion and insulin sensitivity index of each group were compared. Results The index of early phase insulin secretion and insulin sensitivity decreased gradually from NGT → iIGT → IPH, and the difference was statistically significant (P <0.05) after adjustment for age and BM I. Linear regression analysis of patients with iIGT and IPH showed that early phase insulin secretion and insulin sensitivity index were closely related to 2hBG. Conclusions Initial onset of IPH has a marked reduction in early phase insulin secretion and insulin sensitivity. Beta-cell insulin secretion deficiencies and insulin resistance are all determinants of progression from NGT → iIGT → IPH.