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先天性巨结肠(Hirschsprung’s disease,HSCR)是一种由于肠神经嵴细胞迁移失败引起的肠神经系统(enteric nervous system,ENS)发育障碍疾病.其在中国大陆地区的发病率约为1:5000;在消化道先天性畸形疾病中,发病率位居第二.在先天性巨结肠的相关研究中,根据不同的研究内容及目的 采用不同的动物模型进行发病机制与治疗效果等的研究.目前常用于研究先天性巨结肠的动物模型有大鼠模型、小鼠模型、斑马鱼模型以及其他模型(如鸡)等.本文就先天性巨结肠研究国内外常用的动物模型进行介绍.“,”As a developmental disability of enteric nervous system (ENS) ,Hirschsprung’s disease is caused by impaired proliferation and migration of neural crest cells .Its occurrence rate is approximately 1:5000 in mainland China and it ranks the second among congenital gastrointestinal tract malformations . Different kinds of animal models have been employed for examining the pathogenesis and therapies of HSCR according to various objectives and contents .Here we introduced common animal models of HSCR includeing rats ,mouse ,zebrafish and chickens ,etc .