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Two series of 1-(benzoxazole-2-yl)piperazine(Sa-i)and 4-(benzoxazole-2-yl)piperidine compounds(10a-i)were designed, synthesized and evaluated for theirα_1-AR antagonistic activities.Biological assay in vitro indicated that 10h showed slightly strongerα_1-AR antagonistic activity to that of our lead compound 1.
Two series of 1-benzoxazole-2-yl piperazine (Sa-i) and 4- (benzoxazole-2-yl) piperidine compounds (10a-i) were designed, synthesized and evaluated for their α 1-AR antagonistic activities. in vitro indicated that 10hgrade slightly strongerα_1-AR antagonistic activity to that of our lead compound 1.