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目的:探究血清胱抑制素C和血清转化因子-β1在新生儿窒息中的变化及其临床意义。方法:选取2012年1月至2016年9月我院收治的窒息新生儿46例作为窒息组,将同期出生的足月健康新生儿30例作为对照组。分别检测两组新生儿入院后第1、3、7天的血清转化因子-β1(TGF-β1)、血清胱抑制素C(Cys C)、血清尿素氮(BUN)、血清肌酐(Scr)及肾小球滤过率(GFR)水平的变化,并依据是否有肾功能损伤将窒息组46例新生儿分为正常组和损伤组,分析两组新生儿血清指标的变化差异。结果:入院后第1、3、7天,窒息组新生儿的TGF-β1、GFR呈现逐渐升高趋势,且均显著低于对照组(P<0.05);而Cys C、BUN及Scr呈现降低趋势,且均显著高于对照组(P<0.05)。肾功能损伤组的Cys C、BUN及Scr显著高于正常组,TGF-β1、GFR显著低于正常组(P<0.05)。此外,损伤组的TGF-β1水平分别与血清BUN、Scr水平呈负相关关系,与GFR呈正相关关系;而血清Cys C水平分别于血清BUN、Scr呈正相关关系,与GFR呈负相关关系(P均<0.05)。结论:窒息新生儿的血清TGF-β1、Cys C水平均较健康新生儿有显著性变化,并与患儿肾功能显著相关,对患儿肾功能损伤的早期诊断、病情及预后判断有一定的临床指导意义。
Objective: To investigate the changes and clinical significance of serum cystatin C and serum transforming factor-β1 in neonatal asphyxia. Methods: From January 2012 to September 2016,46 neonates with asphyxia admitted to our hospital were selected as the asphyxia group, and 30 healthy newborn babies born at the same period were selected as the control group. The serum levels of TGF-β1, Cys C, BUN and Scr on the 1st, 3rd, 7th day after admission were measured in the two groups of newborns Glomerular filtration rate (GFR) level changes, and based on whether there is renal damage asphyxia group of 46 newborns were divided into normal group and injury group, analysis of changes in the two groups of neonatal serum indicators. Results: On the 1st, 3rd and 7th day after admission, the levels of TGF-β1 and GFR in neonatal asphyxia group were gradually increased, which were significantly lower than those in the control group (P <0.05), while the levels of Cys C, BUN and Scr decreased Trends, and were significantly higher than the control group (P <0.05). The levels of Cys C, BUN and Scr in renal dysfunction group were significantly higher than those in normal group, and the levels of TGF-β1 and GFR were significantly lower than those in normal group (P <0.05). In addition, the levels of TGF-β1 in the injured group were negatively correlated with serum BUN and Scr levels, but positively correlated with GFR. Serum Cys C levels were positively correlated with serum BUN and Scr, but negatively correlated with GFR All <0.05). Conclusion: Serum levels of TGF-β1 and Cys C in neonates with asphyxia have significant changes compared with those in healthy newborns and have significant correlation with renal function in infants. There is a certain degree of early diagnosis, prognosis and prognosis of renal dysfunction in children Clinical guidance.