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目的:探讨65岁以上老年乳腺癌患者的临床特点、治疗方案,分析其预后影响因素。方法:回顾性分析2006年7月至2012年12月收治的160例老年乳腺癌患者的临床资料,采用Kaplan-Meier法和Cox回归法分析各因素对预后的影响。随访率90.6%,随访时间为11-88个月。结果:全组死亡47例,生存113例。浸润性导管癌占全部患者的79.4%。激素受体阳性患者占56.3%。全组患者1,3,5年总生存率分别为95%,74.1%和56.3%。单因素分析显示,组织学分级、肿瘤大小、淋巴结、TNM分期、激素受体、HER2和内分泌治疗是影响预后的因素,而Cox多因素分析结果显示,组织学分级、肿瘤大小、淋巴结、激素受体和HER2是影响预后的独立因素。结论:老年乳腺癌具有独特的临床和病理特点,影响预后的独立因素是组织学分级、肿瘤大小、淋巴结、激素受体和HER2受体。
Objective: To investigate the clinical features and treatment of elderly patients with breast cancer over the age of 65 and analyze the prognostic factors. Methods: The clinical data of 160 elderly patients with breast cancer admitted from July 2006 to December 2012 were retrospectively analyzed. The effects of various factors on the prognosis were analyzed by Kaplan-Meier method and Cox regression analysis. Follow-up rate was 90.6%, followed up for 11-88 months. Results: All the patients died in 47 cases and survived in 113 cases. Invasive ductal cancer accounted for 79.4% of all patients. Hormone receptor positive patients accounted for 56.3%. The overall 1, 3, 5-year overall survival rates were 95%, 74.1% and 56.3%, respectively. Univariate analysis showed that histological grade, tumor size, lymph node, TNM staging, hormone receptor, HER2 and endocrine therapy were the prognostic factors, and Cox multivariate analysis showed that histological grade, tumor size, lymph node, hormone receptor Body and HER2 are independent prognostic factors. CONCLUSIONS: Elderly breast cancer has unique clinical and pathological features. Independent prognostic factors are histological grade, tumor size, lymph node, hormone receptor and HER2 receptor.