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本文对食管癌高发区15～26岁的青少年538例进行了流行病学调查,发现青少年中食管炎很常见,并对其中186例作了食管涂片微核细胞检测。186例中轻度或中度食管炎占2.7%.很轻度19.9%,正常组77.4%。三个组中微核率未见明显差别,且平均微核率在食管炎诊断及家族史、吸烟、口腔粘膜白斑、热饮及新鲜水果的摄入项中也未见差别。结果表明,如果将食管炎作为食管癌发展过程中的一个重要癌前状态,那么对于轻型食管炎微核检测不能作为一个有效的监测手段。
In this paper, 538 cases of adolescents aged 15 to 26 in the high incidence area of esophageal cancer were investigated. It was found that esophagitis was very common in adolescents, and 186 cases of esophageal smear micronuclei cells were detected. In 186 cases, mild or moderate esophagitis accounted for 2.7%, very slight 19.9%, and normal group 77.4%. There was no significant difference in the micronucleus rate among the three groups, and the average micronucleus rate had no difference in the diagnosis of esophagitis, family history, smoking, oral leukoplakia, hot beverage and fresh fruit intake. The results show that if esophagitis is an important precancerous condition during the development of esophageal cancer, micronucleus detection for light esophagitis cannot be used as an effective monitoring tool.