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目的通过对肺炎支原体肺炎(MPP)儿童患者的体液免疫指标结果进行统计分析,探讨体液免疫在MPP发病中的意义。方法选取张家港市中医医院儿科2014年1月到2016年2月期间收治的MPP儿童患者100例为研究对象,设为观察组,同时选取100例健康儿童作为对照组,分别检测两组对象血清中免疫球蛋白(IgG、IgA、IgM)、血清补体(C3和C4)、细胞因子(IL-6和IL-8)及肿瘤坏死因子TNF-α的含量。结果观察组儿童血清中的IgG、IgA、IgM、C3、C4、IL-6、IL-8、TNF-α的水平分别为(9.78±2.63)、(1.24±0.57)、(1.72±0.83)、(1.23±0.28)、(0.29±0.11)、(137.62±27.33)、(119.67±23.18)、(87.41±13.16)pg/ml,均显著高于对照组,差异均有统计学意义(P<0.05)。结论MPP儿童患者的体液免疫发生了改变,可作为临床上肺炎支原体肺炎的辅助诊断。
Objective To analyze the results of humoral immunity in children with Mycoplasma pneumoniae pneumonia (MPP) and discuss the significance of humoral immunity in the pathogenesis of MPP. Methods One hundred children with MPP admitted from January 2014 to February 2016 in Pediatrics of Traditional Chinese Medicine Hospital of Zhangjiagang City were selected as the observation group and 100 healthy children as the control group. Immunoglobulins (IgG, IgA, IgM), serum complement (C3 and C4), cytokines (IL-6 and IL-8) and tumor necrosis factor TNF- Results The levels of serum IgG, IgA, IgM, C3, C4, IL-6, IL-8 and TNF-α in the observation group were 9.78 ± 2.63, 1.24 ± 0.57 and 1.72 ± 0.83, (1.23 ± 0.28), (0.29 ± 0.11), (137.62 ± 27.33), (119.67 ± 23.18) and (87.41 ± 13.16) pg / ml respectively, which were significantly higher than those in the control group ). Conclusion The humoral immunity of MPP children has changed, which can be used as an auxiliary diagnosis for mycoplasma pneumoniae pneumonia in clinic.