【摘 要】
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Alzheimer\'s disease (AD), a common neurodegenerative disease, afflicts 26 million people worldwide currently with projection of a fourfold increase in this figure by the year 2050 (Brookmeyer et al., 2018). The majority of AD cases (95％) are sporadic,
【机 构】
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School of Pharmacy and Bioengineering, Keele University, Staffordshire, UK
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Alzheimer\'s disease (AD), a common neurodegenerative disease, afflicts 26 million people worldwide currently with projection of a fourfold increase in this figure by the year 2050 (Brookmeyer et al., 2018). The majority of AD cases (95％) are sporadic, having the late-onset affecting those over 65 years old. About 15％ among those 65 years and older suffer from AD, and the incidence of AD is close to 50％ for those aged over 85 years (Brookmeyer et al., 2018). There are a number of changes in the ageing brain, such as reduced cerebral blood flow, white matter changes, iron overload, and neuroinflammation (Chen et al., 2010). The reduction of cerebral blood flow leads to hypoperfusion, thus causing cerebral hypoxia, which is a common vascular component among the AD risk factors. Prolonged and severe hypoxia can cause neuronal loss and memory impairment. It has been understood that patients with stroke are at risk of AD. Up to 1/3 of stroke survivors suffer from post stroke dementia (Mijajlovic et al., 2017). The most common cause of post stroke dementia are vascular dementia, AD and mixed dementia.
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