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为增强抗白血病药物敏感性 ,采用液体培养法研究环孢霉素 A(CSA)与硫氮酮 (DZ)单用或合用分别增强 K56 2细胞、耐药 K56 2细胞 (K56 2 /Adr)对阿霉素 (Adr)、足叶乙甙 (VP16 )两种化疗药物敏感性的增强作用。结果表明在 K56 2及 K56 2 /Adr细胞中 ,单用硫氮酮较高浓度 (2 2 1.7μmol/L)时才呈现对 Adr或 VP16敏感性的增强作用 ;单用 CSA较高浓度 (4.2 μmol/L)时增强 Adr对 K56 2细胞的杀伤性而对 VP16增强作用则不明显 ,较高浓度 CSA(4.2μmol/L )均能提高 K56 2 /Adr细胞对Adr或 VP16的敏感性 ;采用低浓度的 CSA(1.3μmol/L )和硫氮酮 (2 .2μmol/L )联合作用于 K56 2 /Adr细胞 ,呈现对 VP16或 Adr药物敏感性的明显增加。提示 CSA与 DZ合用能减少用量而有效地加强耐药细胞对化疗药物的敏感性
To enhance the sensitivity of anti-leukemia drugs, the liquid culture method was used to study cyclosporin A (CSA) and sulfazenone (DZ) alone or in combination to enhance K56 2 cells and K562 2 cells (K56 2 /Adr), respectively. Increased susceptibility to two chemotherapy drugs, adromycin (Adr) and etoposide (VP16). The results showed that in K562 and K562/Adr cells, the higher concentration of sulfatranone alone (221.7mol/L) showed enhanced sensitivity to Adr or VP16; higher CSA concentrations alone ( At the concentration of 4.2 μmol/L, the killing effect of Adr on K56 2 cells was enhanced but that on VP16 was not obvious. The higher concentration of CSA (4.2 μmol/L) increased the sensitivity of K56 2 /Adr cells to Adr or VP16. Low concentrations of CSA (1.3 μmol/L) and sulfazone (2.2 μmol/L) were used in combination with K56 2 /Adr cells to show a significant increase in susceptibility to VP16 or Adr drugs. The combination of CSA and DZ can reduce the dosage and effectively enhance the sensitivity of drug-resistant cells to chemotherapy drugs.