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从肝癌高发的扶绥县主粮中分离出5株杂色曲霉接种于玉米培养基培养并制备其有机提取液,分别用Ames试验、枯草杆菌重组修复试验和原噬菌体诱导检测法对杂色曲霉提取液进行遗传毒性测定。结果5株杂色曲霉提取液均显示不同程度的致突变性,表明肝癌高发县主粮中杂色曲霉产毒株的普遍存在,并提示对肝癌的发病率可能起一定作用。
Five strains of Aspergillus versicolor were isolated and inoculated into maize medium from the staple food of Fusui County with high incidence of liver cancer. The organic extracts were prepared and purified by Ames test, Bacillus subtilis recombinant test and prophage detection. Liquid for genotoxicity determination. Results All of the five Aspergillus versicolor extracts showed different degrees of mutagenicity, indicating that the prevalence of Aspergillus versicolor - producing strains in the staple food of high incidence of hepatocellular carcinoma is quite common and suggests that it may play a role in the incidence of hepatocellular carcinoma.