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目的探讨传统抗癫痫药、抗癫痫新药及中医药或维吾尔医药治疗对癫痫患儿睡眠呼吸的影响。方法将85例患者随机分为传统抗癫痫药物组(A组,30例)、抗癫痫新药组(B组,28例)、中医药或维吾尔医药治疗组(C组,27例),分别在治疗前、治疗1a后、治疗2a后及治疗3a后在非发作期用多导睡眠监测仪(PSG)测定并记录患儿睡眠期图形,判定并分析在长期治疗前后患儿的睡眠呼吸失常的相关指标状况,将3组间睡眠呼吸状况参数进行对比。结果 PSG测定发现治疗前3组患儿总体睡眠呼吸障碍发生百分率为5.50%,呼吸暂停低通气指数(AHI)为(7.23±0.21),均为轻度阻塞性睡眠呼吸暂停低通气综合征;治疗1a后的发生百分率为6.12%,AHI为(7.56±0.32);治疗2a后的发生百分率为6.23%,AHI为(8.65±0.37),其中A、C组各发现1例轻度中枢性睡眠呼吸暂停低通气综合征;治疗3a后的发生百分率为6.65%;AHI为(12.56±0.47),其中A、C组各发现1例轻度和中度混合型睡眠呼吸暂停低通气综合征,同时A组检测出中枢型睡眠呼吸暂停低通气综合征1例。治疗前后睡眠呼吸障碍发生百分率和AHI差异均有统计学意义(P<0.05);组间比较睡眠呼吸障碍发生百分率和AHI差异均有统计学意义(P<0.05)。结论长期使用抗癫痫药物可加重失眠,有镇静作用的抗痫药物还会加重睡眠期呼吸暂停的危险,但新型抗癫痫药物具有促进睡眠稳定性和正常化的作用,要根据睡眠结构和对睡眠呼吸障碍的影响选择抗癫痫药物。
Objective To investigate the effects of traditional antiepileptic drugs, antiepileptic drugs and traditional Chinese medicine or Uyghur medicine on sleep apnea in children with epilepsy. Methods Eighty-five patients were randomly divided into two groups: traditional antiepileptic group (A group, 30 cases), antiepileptic group (B group, 28 cases), Chinese medicine or Uyghur medicine group (C group, 27 cases) Before treatment, after treatment 1a, after treatment 2a and after treatment 3a in non-attack phase with polysomnography (PSG) measured and recorded in children with sleep patterns, to determine and analyze the long-term treatment of children with sleep apnea Relevant indicators of the situation, the three groups of sleep breathing parameters were compared. Results The percentage of sleep apnea was 5.50% and the apnea-hypopnea index (AHI) was (7.23 ± 0.21) in the three groups before treatment, all of which were mild obstructive sleep apnea-hypopnea syndrome The percentage of occurrence after 1a was 6.12% and the value of AHI was (7.56 ± 0.32). After treatment 2a, the percentage of occurrence was 6.23% and AHI was (8.65 ± 0.37) respectively. One case of mild central sleep respiration Hypopnea syndrome was halted. The incidence of Hypopnea syndrome after treatment for 3 years was 6.65% and AHI was (12.56 ± 0.47). One case of mild and moderate mixed sleep apnea-hypopnea syndrome was found in groups A and C, and A One case of central sleep apnea-hypopnea syndrome was detected. The percentage of sleep disordered breathing and AHI before and after treatment were significantly different (P <0.05). There were significant differences in the percentage of sleep disordered breathing and AHI between two groups (P <0.05). Conclusion Long-term use of antiepileptic drugs can aggravate insomnia. Sedative antiepileptic drugs may further aggravate the risk of apnea during sleep. However, antiepileptic drugs can promote the stability and normalization of sleep. According to the structure of sleep and the effects on sleep Effects of Respiratory Disorders Select antiepileptic drugs.